Lab-on-fiber technology: a new avenue for optical nanosensors

The "lab-on-fiber" concept envisions novel and highly functionalized technological platforms completely integrated in a single optical fiber that would allow the development of advanced devices, components and sub-systems to be incorporated in modern optical systems for communication and sensing applications. The realization of integrated optical fiber devices requires that several structures and materials at nano- and micro-scale are constructed, embedded and connected all together to provide the necessary physical connections and light-matter interactions. This paper reviews the strategies, the main achievements and related devices in the lab-on-fiber roadmap discussing perspectives and challenges that lie ahead

Near-Field Opto-Chemical Sensors

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Near field behavior of SnO 2 particle-layer deposited on standard optical fiber by electrostatic spray pyrolysis method

We report the emergent optical near field profiles from standard single mode optical fibers on the cleaved end of which were deposited particle layers of SnO(2). The layers, composed of micron and sub-micron sized particles, were deposited by means of Electrostatic Spray Pyrolysis (ESP) technique. Powerful analytical tools such as Atomic Force Microscopy (AFM) and Scanning Near-field Optical Microscopy (SNOM) were used to obtain simultaneously the SnO(2) layers topography and the related optical near field intensity distribution, when the fiber-substrate is illuminated by a light radiation in NIR range. We show that isolated microstructures, positioned in correspondence of the fiber core, reveal highly unusual capability of locally enhancing the collected optical near field. The observed phenomenon leads to new concepts of fiber optic chemical sensors and in fiber microsystems as well

One year of FBG-based thermo-hygrometers in operation in the CMS experiment at CERN

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Electric Field Bridging-Effect in Electrified Microfibrils’ Scaffolds

Introduction: The use of biocompatible scaffolds combined with the implantation of neural stem cells, is increasingly being investigated to promote the regeneration of damaged neural tissue, for instance, after a Spinal Cord Injury (SCI). In particular, aligned Polylactic Acid (PLA) microfibrils’ scaffolds are capable of supporting cells, promoting their survival and guiding their differentiation in neural lineage to repair the lesion. Despite its biocompatible nature, PLA is an electrically insulating material and thus it could be detrimental for increasingly common scaffolds’ electric functionalization, aimed at accelerating the cellular processes. In this context, the European RISEUP project aims to combine high intense microseconds pulses and DC stimulation with neurogenesis, supported by a PLA microfibrils’ scaffold. Methods: In this paper a numerical study on the effect of microfibrils’ scaffolds on the E-field distribution, in planar interdigitated electrodes, is presented. Realistic microfibrils’ 3D CAD models have been built to carry out a numerical dosimetry study, through Comsol Multiphysics software. Results: Under a voltage of 10 V, microfibrils redistribute the E-field values focalizing the field streamlines in the spaces between the fibers, allowing the field to pass and reach maximum values up to 100 kV/m and values comparable with the bare electrodes’ device (without fibers). Discussion: Globally the median E-field inside the scaffolded electrodes is the 90% of the nominal field, allowing an adequate cells’ exposure

Radiation hard polyimide-coated FBG optical sensors for relative humidity monitoring in the CMS experiment at CERN

This work investigates the performance and the radiation hardness capability of optical thermo-hygrometers based on Fibre Bragg Gratings (FBG) for humidity monitoring in the Compact Muon Solenoid (CMS), one of the four experiments running at CERN in Geneva. A thorough campaign of characterization was performed on 80 specially produced Polyimide-coated RH FBG sensors and 80 commercial temperature FBG sensors. Sensitivity, repeatability and accuracy were studied on the whole batch, putting in evidence the limits of the sensors, but also showing that they can be used in very dry conditions. In order to extract the humidity measurements from the sensor readings, commercial temperature FBG sensors were characterized in the range of interest. Irradiation campaigns with ionizing radiation (gamma-rays from a Co-60 source) at incremental absorbed doses (up to 210 kGy for the T sensors and up to 90 kGy for the RH sensors) were performed on sample of T and RH-Sensors. The results show that the sensitivity of the sensors is unchanged up to the level attained of the absorbed dose, while the natural wavelength peak of each sensor exhibits a radiation-induced shift (signal offset). The saturation properties of this shift are discussed

Lab-on-fiber technology

This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the "lab-on-fiber" technology. Inspired by the well-established 'lab on-a-chip' concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications.Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate d

Burr Holes Revascularization in Three Pediatric Cases of Moyamoya Syndrome: Easy Choice or Insidious Trap? Case Series and Review

Moyamoya disease is a steno-occlusive cerebrovascular disease of unknown etiology involving the terminal portion of the internal carotid artery and the proximal portions of the anterior and middle cerebral arteries with associated collateral vascular network. When the vascular pattern is associated with a particular condition (e.g., Type 1 neurofibromatosis, Down syndrome), it is defined as moyamoya syndrome (MMS) (or quasi-moyamoya). Among different indirect bypass techniques used to prevent ischemic injury by increasing collateral blood flow to hypoperfused areas of the cortex, multiple burr holes technique is an easy and diffuse indirect revascularization approach in the treatment of moyamoya